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Target intelligence / Profile preview
Vibrio cholerae Lipopolysaccharide O-antigen (LPS O-antigen)
- Target
- LPS O-antigen
- Molecular classification
- Lipopolysaccharide, Polysaccharide, Surface Antigen
01
Overview
The Vibrio cholerae lipopolysaccharide's O-antigen defines major serogroups responsible for epidemic/pandemic disease. It is an essential virulence factor, facilitating colonization and immune evasion, and an effective immunogen targeted by natural infection-induced immunity and vaccines. Phase variation allows rapid adaptation under selective pressure.
- Other names
- Vibrio cholerae surface antigenV. cholerae LPSO1 antigenO139 antigen
02
Mechanism of action
Antibodies inhibit bacterial colonization and promote complement-mediated lysis.
03
Biological functions
Immune evasionHost cell interactionColonizationBiofilm formationSerogroup determination
04
Disease associations
InfectionCholeraGastrointestinal disease
05
Safety considerations
Potential for inducing inflammatory responsesSerotype variability and vaccine efficacyPhase variation
06
Interacting drugs
Vibriocidal antibodies
1 more in the full profile.
07
Biomarkers
Vibriocidal antibody titers (IgM, IgA)LPS serotype
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