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Target intelligence / Profile preview
Vibrio cholerae O-specific Polysaccharide Antigen (OSP)
- Target
- OSP
- Molecular classification
- Polysaccharide, Lipopolysaccharide component, Antigen
01
Overview
The O-specific polysaccharide (OSP) antigen of *Vibrio cholerae* is a key structural and immunogenic component of the bacterium’s lipopolysaccharide (LPS) layer. It forms the outermost domain of LPS, projecting from the bacterial surface, and is responsible for serogroup specificity in *V. cholerae*. The structure and composition of this antigen vary between different serogroups, most notably O1 and O139, which are associated with epidemic cholera. It is a target for diagnostics and vaccine development.
- Other names
- V. cholerae O-antigenO-specific polysaccharideO-antigenVibrio cholerae LPS O-antigenVibrio cholerae serogroup-specific polysaccharide
02
Mechanism of action
N/A
03
Biological functions
Serotype determinationImmune recognitionVirulence factorCapsule component (O139)Elicits antibody response
04
Disease associations
InfectionCholeraImmune evasion
05
Safety considerations
Serogroup specificity of immune responsesLimited cross-protection between serogroupsVariable immunogenicity of current vaccines
06
Biomarkers
Anti-OSP antibodies (as a correlate of protection)
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