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Target intelligence / Profile preview
Vibrio cholerae O1 and O139 (N/A)
- Target
- N/A
- Molecular classification
- Bacterium, Gram-negative bacterium
01
Overview
Vibrio cholerae O1 and O139 are serogroups of the bacterium Vibrio cholerae responsible for epidemic and pandemic cholera in humans. They are differentiated by the structure of their lipopolysaccharide (LPS) O-antigen. Both serogroups produce cholera toxin (CTX), which causes severe watery diarrhea. V. cholerae O139 is encapsulated, unlike V. cholerae O1. Transmission occurs primarily via contaminated water or food.
- Other names
- V. cholerae O1V. cholerae O139Cholera-causing Vibrio choleraeEpidemic Vibrio cholerae
02
Mechanism of action
N/A
03
Biological functions
PathogenesisColonizationToxin productionInfection
04
Disease associations
CholeraDiarrheal diseaseGastroenteritis
05
Safety considerations
Antibiotic resistanceVaccine efficacy in specific populationsPotential for asymptomatic carriage
06
Interacting drugs
Antibiotics (e.g., tetracycline, doxycycline, azithromycin)
2 more in the full profile.
07
Biomarkers
Vibrio cholerae O1 and O139 detection in stool samplesCholera toxin (CTX) detectionAntibody response to LPS O-antigen
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