Vibrio cholerae O1 lipopolysaccharide O-antigen (null)

The Vibrio cholerae O1 lipopolysaccharide O-antigen is a heat-stable polysaccharide found on the outer membrane of V. cholerae and is the principal determinant of the O1 serogroup[5][6]. It serves as the major surface antigen recognized by the host immune system, the primary target for protective antibody responses, and the receptor for certain bacteriophages[1][2][7]. Serogroup O1 strains, defined by the structure of this antigen, are responsible for epidemic and pandemic cholera, and the antigen's structural variants (serotypes Ogawa, Inaba, Hikojima) contribute to epidemiological diversity[5][7]. The O-antigen is central to current vaccine design and diagnostic efforts, but it is subject to phase variation and antigenic change, which can influence infectivity, immune evasion, and resistance to phage therapy[1][6][7]. Note: The term "Vibrio cholerae surface antigen" is not specific, and could equally refer to other surface structures, such as outer membrane proteins or alternative polysaccharide antigens. For structured scientific or therapeutic purposes, Vibrio cholerae O1 lipopolysaccharide O-antigen (or O1 antigen) is the precise canonical form for the major, therapeutically relevant surface antigen[1][5][7]. Further specification is necessary to avoid ambiguity.

Other names

O-antigen of Vibrio choleraeLipopolysaccharide O-antigenV. cholerae O1 antigenO1 surface polysaccharide

Induction of protective immunity through generation of O-antigen–specific antibodies (as with killed whole-cell or conjugate vaccines). Bacteriophage therapy utilizes phages that recognize and bind the O-antigen to infect and lyse the bacterium.