Vibrio cholerae O1 Ogawa and Inaba lipopolysaccharide antigen (null)

The **Vibrio cholerae O1 Ogawa and Inaba lipopolysaccharide (LPS) antigen** is a major surface polysaccharide of *Vibrio cholerae* O1, the dominant cause of cholera epidemics[1][5][9]. Its structure consists of lipid A, a core oligosaccharide, and a repeating O-specific polysaccharide (O-SP). The Ogawa and Inaba serotypes differ by a single chemical modification: the Ogawa serotype's terminal perosamine unit is 2-O-methylated, while the Inaba terminal perosamine has a hydroxyl group at that position[1][3][5][9]. This small difference results in distinct antigenic properties, which dictate serotype-specific immune recognition and are targets for vibriocidal antibodies after infection or vaccination[5][9]. Anti-LPS antibodies are strong correlates of cholera protection, making these antigens central to subunit vaccine and monoclonal antibody development[5][1]. Because LPS is also an endotoxin, there are potential concerns about reactogenicity if large doses are administered, but in the context of natural infection and vaccination, these antigens are essential mediators of both disease and protective immunity[1][5].

Other names

Vibrio cholerae O1 LPS OgawaVibrio cholerae O1 LPS InabaV. cholerae O1 LPSV. cholerae O1 O-specific polysaccharide (O-SP)Ogawa LPSInaba LPSCholera LPS antigen

Induction of protective antibody responses (by immune system or vaccine); Antibody-mediated neutralization