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Target intelligence / Profile preview
Vibrio cholerae O1 Surface Antigen (O1 Antigen)
- Target
- O1 Antigen
- Molecular classification
- Lipopolysaccharide, Polysaccharide, Surface Antigen
01
Overview
The Vibrio cholerae O1 surface antigen is a key component of the bacterium's outer membrane lipopolysaccharide (LPS), defining the O1 serogroup responsible for epidemic and pandemic cholera. It functions as a phage receptor, a major target for host immune responses, and contributes to bacterial virulence by protecting against complement-mediated killing and facilitating colonization. Vaccines targeting this antigen aim to elicit protective immunity.
- Other names
- V. cholerae O1 LPSO1 PolysaccharideO1 Antigen
02
Mechanism of action
Neutralization of bacteria, complement-mediated killing, stimulation of antibody production.
03
Biological functions
Serotype determinantBacteriophage receptorImmune system targetVirulence factorColonization factor
04
Disease associations
CholeraInfection
05
Safety considerations
Phase variation leading to immune evasionPotential for serotype replacementLimited coverage of O139 and non-O1/non-O139 serogroups
06
Interacting drugs
Anti-LPS antibodies
2 more in the full profile.
07
Biomarkers
Anti-O1 antibodies (for vaccine efficacy)O1 antigen detection (for diagnosis)
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