Vibrio cholerae surface antigen

Vibrio cholerae surface antigens comprise a range of cell-associated molecules exposed to the environment, most notably the O-antigen, a strain-defining sugar component of lipopolysaccharide (LPS) that mediates immune recognition, as well as various protein adhesins (e.g., GbpA, Bap1, RbmC) that play crucial roles in tissue colonization, biofilm formation, and host-pathogen interactions[5][3][2][6][7]. These antigens are essential for diagnosis (serotyping), vaccine development, passive immunotherapies, and as biomarkers for epidemiological surveillance. The “surface antigens” term is imprecise; for structured biomedical use, the O-antigen (or its subtypes), named adhesins, and specific outer membrane proteins are recommended as separate canonical targets. Surface antigen diversity represents both a scientific challenge and an opportunity for intervention in the prevention and management of cholera. Notable subtypes and examples (best represented as separate entries for specificity): - O-antigen (lipopolysaccharide polysaccharide chain) - GbpA (N-acetylglucosamine-binding protein A) - Bap1 (biofilm-associated protein 1) - RbmC (rugosity and biofilm structure modulator C) If deeper structured information is required, input should specify one of these (e.g., “Vibrio cholerae O-antigen”), as “surface antigen” is a collection of diverse molecules without a single canonical molecule or target.

Other names

V. cholerae O-antigenO-specific polysaccharideLipopolysaccharide O-antigen (LPS O-antigen)Surface adhesinsVibrio cholerae cell surface antigen (generic)

Vaccine-induced antibodies bind O-antigen or surface adhesins, promoting bacterial agglutination, opsonization, complement activation, and reduced motility[6][5]. Monoclonal antibodies can crosslink O-antigen and inhibit bacterial motility or colonization[6]. Phage binds and lyses bacteria via O-antigen or surface carbohydrates[4].