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Target intelligence / Profile preview
Vimentin (VIM)
- Target
- VIM
- Molecular classification
- Intermediate Filament, Type III Intermediate Filament
01
Overview
Vimentin is a type III intermediate filament protein predominantly expressed in mesenchymal cells. It provides structural support and maintains cellular integrity. It is involved in cell adhesion, migration/motility, plasticity, mechanosensing/transduction pathways, contractility, inflammatory responses, and tissue regeneration. Vimentin overexpression or abnormal regulation has been linked to cancer progression/metastasis, autoimmune diseases, and infectious diseases. It is considered a potential therapeutic target due to its role in cell motility/invasion/adhesion/remodeling processes.
02
Mechanism of action
Inhibition of vimentin polymerization/interaction with other proteins
03
Biological functions
Cytoskeletal supportOrganelle anchoringCell migrationCell motilityCell plasticityMechanosensingMechanotransductionCell adhesionContractilityInflammatory responseTissue regenerationCholesterol metabolism
04
Disease associations
Cancer progressionCancer metastasisAutoimmune diseasesRheumatoid arthritisCrohn’s diseaseInfectious diseasesHIVSARS-CoVDengue virus
05
Safety considerations
Potential for off-target effects due to widespread expressionChallenges in selectively targeting vimentin in specific cell types or tissues
06
Biomarkers
EMT marker in cancerPrognostic marker in cancer
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