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Target intelligence / Profile preview
Viral attachment protein gp120 (gp120)
- Target
- gp120
- Molecular classification
- Viral envelope glycoprotein
01
Overview
Gp120 is a viral envelope glycoprotein found on the surface of HIV particles. It plays a critical role in the virus's ability to attach to and enter host cells by binding to CD4 and chemokine co-receptors on T-helper lymphocytes.
02
Mechanism of action
Blocking interaction with CD4, preventing HIV attachment to target cells
03
Biological functions
Viral attachmentMembrane fusion
04
Disease associations
Infection
05
Safety considerations
High concentrations during infection can dysregulate T-cell function
06
Interacting drugs
Gp120 inhibitors
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