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Target intelligence / Profile preview
Viral DNA Polymerase Catalytic Subunit
- Molecular classification
- Enzyme, Polymerase
01
Overview
The viral DNA polymerase catalytic subunit is a core enzyme responsible for the replication of viral genomic DNA. It is essential for the synthesis of new viral genomes during infection and plays a central role in the assembly and function of the viral replication complex. It catalyzes the synthesis of DNA from deoxyribonucleotides, using an existing strand as a template and possesses 3'-5' exonuclease activity, providing proofreading capability. In some viruses, it includes intrinsic ribonuclease H (RNase H) activity.
02
Mechanism of action
Inhibition of viral DNA polymerase activity, chain termination
03
Biological functions
DNA replicationGenome replicationProofreadingRNA primer removal (in some viruses)
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistanceOff-target effects
06
Interacting drugs
Acyclovir
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