Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Viral envelope glycoprotein gp120 (gp120)
- Target
- gp120
- Molecular classification
- Viral envelope glycoprotein, Glycoprotein
01
Overview
Viral envelope glycoprotein gp120 is a surface glycoprotein on the HIV envelope that mediates viral entry into host cells. It binds to CD4 receptors and chemokine co-receptors (CCR5 or CXCR4) on host cells, initiating membrane fusion. Its high sequence variability and extensive glycosylation pose significant challenges for vaccine development and antibody-based therapies. It exists in complex with transmembrane protein gp41 in trimeric spikes.
- Other names
- GP120HIV-1 gp120Glycoprotein 120
02
Mechanism of action
Targeted by antibodies to prevent binding to CD4 receptor and subsequent steps in HIV entry. Also targeted for vaccine development to elicit neutralizing antibodies.
03
Biological functions
Viral entry into host cellsCD4 receptor bindingCCR5/CXCR4 co-receptor engagementMembrane fusionImmune evasion
04
Disease associations
InfectionHIV infectionAIDS
05
Safety considerations
High sequence variability leading to immune escapeGlycan shield masking conserved epitopesDifficulty in eliciting broadly neutralizing antibodies through vaccinationConformational masking of receptor-binding sites
Beyond the preview
Go deeper on Viral envelope glycoprotein gp120 (gp120).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Viral envelope glycoprotein gp120 (gp120).