Viral gene transfer

Viral gene transfer refers to the use of viruses or viral vectors to deliver genetic material (transgenes) into target cells, either for genetic modification, as part of gene therapy protocols, or for research[5][1]. Common virus types used include retroviruses (including lentiviruses), adenoviruses, adeno-associated viruses, and herpes simplex virus[5][1][3]. These viral vectors have evolved natural mechanisms for cell entry and efficient gene delivery, making them effective tools for transducing a variety of cell types[5][1]. In gene therapy, the viral vector is engineered to be replication-deficient and to carry a therapeutic gene. The process is associated with certain challenges and risks, including immune responses, limitations in the size of the genetic payload, risk of insertional mutagenesis (integration into the host genome), and possible safety issues such as cytotoxicity and unintentional modification of non-target cells[1][3][5]. "Viral gene transfer" describes the delivery method, not a druggable protein or structure. If you are looking for information on a specific viral vector (e.g., "Adenovirus"), a specific viral gene product, or a receptor that mediates viral entry (e.g., "Coxsackievirus and adenovirus receptor"), please clarify for more targeted data.

Other names

Viral-mediated gene deliveryViral vector gene deliveryVirus-mediated gene transfer