Target intelligence / Profile preview

Viral Integrase (IN)

Target: IN
Molecular classification: Enzyme, Viral protein

Overview

Viral integrase is an essential enzyme produced by retroviruses, such as HIV, that catalyzes the integration of viral DNA into the host cell genome. This process is a critical step in establishing a permanent infection and enables the replication and persistence of the virus within host cells. Integrase inhibitors are key components in antiretroviral therapy for HIV/AIDS, blocking genome integration and halting infection progression.

Other names: Retroviral IntegraseIntegrase enzyme

Mechanism of action

Integrase inhibitors block either strand transfer or allosteric sites on integrase, preventing successful genome integration.

Biological functions

Integration of viral DNA into host genomeDNA cleavageDNA strand transferViral replication

Disease associations

InfectionHIV/AIDS

Safety considerations

Drug resistanceAdverse drug reactions

Interacting drugs

Raltegravir

3 more in the full profile.

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