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Target intelligence / Profile preview
Viral mRNA Guanylyltransferase (N/A)
- Target
- N/A
- Molecular classification
- Enzyme
01
Overview
Viral mRNA guanylyltransferase is an enzyme that catalyzes the addition of a guanosine cap to the 5' end of viral mRNA transcripts. This capping process is essential for mRNA stability and translation efficiency. The enzyme transfers GMP from GTP to the 5'-triphosphate or diphosphate terminus of RNA, forming the cap structure G(5')ppp(5')N. Examples include NSP14 in SARS-CoV-2 and the guanylyltransferase of vaccinia virus. Inhibitors targeting this enzyme could disrupt viral mRNA capping, affecting viral replication and translation.
02
Mechanism of action
Inhibition of guanylyltransferase activity, disrupting viral mRNA capping
03
Biological functions
mRNA cappingmRNA stabilityTranslation initiation
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects on host cell mRNA capping.Development of resistance.
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