Viral RNA-dependent RNA Polymerase (RdRp)

Viral RNA-dependent RNA polymerase (RdRp) is an enzyme found in RNA viruses that catalyzes the synthesis of RNA from an RNA template. It is essential for viral replication and transcription and is a key target for antiviral drug development due to its absence in host cells. RdRp lacks proofreading activity, contributing to high viral mutation rates. Its structure features conserved motifs within fingers, palm, and thumb subdomains, critical for catalysis and nucleotide binding.

Other names

RNA-dependent RNA polymeraseRNA replicaseViral polymerase

Inhibition of RNA-dependent RNA polymerase activity, leading to termination of viral RNA synthesis.