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Target intelligence / Profile preview
Viral Protein 35 (VP35)
- Target
- VP35
- Molecular classification
- Viral protein, Polymerase cofactor, Immune antagonist, Structural protein
01
Overview
VP35 is a multifunctional protein encoded by filoviruses, most notably the Ebola virus (EBOV). It plays critical roles in viral replication, immune evasion, and pathogenesis. VP35 is not an enzyme but acts as a cofactor and structural component within the viral machinery. It serves as a nonenzymatic component of the viral RNA synthesis machinery, suppresses host innate immune responses by inhibiting RIG-I signaling pathways, interferes with dendritic cell maturation, and suppresses RNA interference (RNAi).
- Other names
- eVP35EBOV VP35
02
Mechanism of action
Disruption of dsRNA binding, inhibition of RIG-I signaling, interference with NP interaction, inhibition of PKR autophosphorylation.
03
Biological functions
Viral replicationImmune evasionInterferon inhibitionSuppression of dendritic cell maturationRNA silencing suppression
04
Disease associations
InfectionEbola virus disease
05
Safety considerations
Potential for off-target effects on host RNA metabolismDevelopment of viral resistance
06
Interacting drugs
Small molecules targeting IID domain
1 more in the full profile.
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