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Target intelligence / Profile preview
Viral Thymidine Kinase (Viral TK)
- Target
- Viral TK
- Molecular classification
- Enzyme, Kinase, Viral Enzyme
01
Overview
Viral thymidine kinase (TK) is an enzyme encoded by certain viruses, most notably members of the Herpesviridae family. It plays a crucial role in the viral life cycle by facilitating DNA synthesis through the phosphorylation of thymidine and activation of antiviral prodrugs such as acyclovir and ganciclovir. Its broad substrate specificity distinguishes it from cellular thymidine kinases, making it an important target for antiviral therapy and a tool for gene therapy.
- Other names
- HSV-TKVZV-TKViral TKHerpes Simplex Virus Thymidine KinaseVaricella-Zoster Virus Thymidine Kinase
02
Mechanism of action
Phosphorylation of nucleoside analogs, leading to inhibition of viral DNA polymerase and/or chain termination.
03
Biological functions
Nucleoside phosphorylationDNA synthesisPyrimidine salvage pathwayActivation of antiviral prodrugs
04
Disease associations
InfectionHerpes simplex virus infectionsVaricella-zoster virus infectionsDrug resistance
05
Safety considerations
Drug resistance due to mutations in the tk geneOff-target effects in gene therapy applicationsPotential for immune response against HSV-TK expressing cells
06
Interacting drugs
Acyclovir
4 more in the full profile.
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