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Target intelligence / Profile preview
Virion Capsid Protein VP1 (VP1)
- Target
- VP1
- Molecular classification
- Structural Protein, Capsid Protein
01
Overview
Virion capsid protein VP1 is the major structural protein of the polyomavirus family and related viruses. It forms the main component of the viral capsid, which is responsible for protecting viral genetic material and mediating initial interactions with host cells during infection. It initiates infection by binding to sialic acids present on cell-surface glycans and is capable of self-organizing into virus-like particles. VP1 also binds directly to microtubules, stabilizing them and potentially affecting host cell cycle progression.
02
Biological functions
Cell entryReceptor bindingSelf-assemblyGenome packagingMicrotubule stabilizationNuclear transport
03
Disease associations
Infection
04
Safety considerations
Potential for cell cycle arrestMicrotubule stabilization may have off-target effects
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