Target intelligence / Profile preview

Virus-induced DNA Polymerase

Molecular classification
Enzyme, DNA-dependent DNA Polymerase, Viral family B DNA polymerase, Viral family A DNA polymerase, Viral family X DNA polymerase, Viral family Y DNA polymerase
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Overview

Virus-induced DNA polymerases are enzymes encoded by viruses that catalyze the synthesis of DNA from a DNA template during viral genome replication. These polymerases are essential for the replication and propagation of many DNA viruses, especially those that replicate in environments where host cell polymerases are unavailable or insufficient. They are targets for antiviral drugs.

Other names
Virus-coded DNA PolymeraseViral DNA PolymeraseDdDp
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Mechanism of action

Inhibition of viral DNA synthesis

03

Biological functions

Viral genome replicationDNA synthesisProofreadingElongation of DNA strand
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Disease associations

InfectionHerpesvirus infectionsPoxvirus infections
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Safety considerations

Potential for off-target effects if inhibitors are not highly specificDevelopment of drug resistance

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