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Vitamin A Pathway (N/A)
- Target
- N/A
- Molecular classification
- Metabolic Pathway, Signaling Pathway
01
Overview
The Vitamin A pathway encompasses the absorption, metabolism, transport, cellular uptake, and signaling of vitamin A and its derivatives (retinoids). It's vital for vision, immune function, cellular differentiation, embryonic development, reproduction, and epithelial tissue maintenance. The pathway involves various molecules like retinol, retinal, retinoic acid, retinyl esters, and provitamin A carotenoids. Dietary sources include animal products and colored vegetables. Absorption, transport via RBP4, cellular uptake via STRA6, and conversion to retinoic acid are key steps. Retinoic acid then acts on nuclear receptors (RARs, RXRs, PPARβ) to regulate gene expression. Feedback loops involving Cyp26 enzymes control pathway activity. Deficiencies or excesses can lead to significant health issues.
- Other names
- Retinoid PathwayRetinoic Acid Signaling PathwayVitamin A Metabolism
02
Mechanism of action
N/A
03
Biological functions
VisionImmune responseCellular differentiationCell proliferationEmbryonic developmentReproductionEpithelial maintenance
04
Disease associations
Vitamin A DeficiencyCancerImmune DisordersDevelopmental AbnormalitiesEye DisordersSkin Disorders
05
Safety considerations
Hypervitaminosis A (Vitamin A Toxicity)Teratogenicity (Retinoids during pregnancy)Liver toxicityDrug interactions (e.g., with tetracyclines)
06
Interacting drugs
Retinoids (e.g., Isotretinoin, Tretinoin)
2 more in the full profile.
07
Biomarkers
Serum Retinol LevelsRetinol-Binding Protein 4 (RBP4)Beta-carotene levels
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