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Target intelligence / Profile preview
Vitamin B12 Metabolic Pathway (B12 Pathway)
- Target
- B12 Pathway
- Molecular classification
- Metabolic Pathway
01
Overview
The Vitamin B12 metabolic pathway encompasses dietary absorption, transport through the bloodstream bound to specific proteins, cellular uptake via receptor-mediated endocytosis, intracellular trafficking and conversion to active coenzyme forms (methylcobalamin and adenosylcobalamin), and its roles as an enzymatic cofactor. It's crucial for DNA synthesis, methylation, fatty acid and amino acid metabolism, and nervous system function.
- Other names
- Cobalamin MetabolismB12 PathwayMethylcobalamin and Adenosylcobalamin Synthesis and Utilization
02
Biological functions
DNA synthesisMethylation reactionsFatty acid metabolismAmino acid metabolismNervous system maintenanceEnergy production
03
Disease associations
Megaloblastic anemiaNeurological disordersHomocysteinemia
04
Safety considerations
MalabsorptionGenetic defects affecting B12 metabolismDietary deficiency (vegan diets)
05
Biomarkers
Serum B12 levelsMethylmalonic acid (MMA)Homocysteine
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