Vitamin B6 Pathway (B6 Pathway)

The vitamin B6 pathway encompasses the metabolic processes responsible for the synthesis (in bacteria, fungi, and plants), interconversion, and utilization of vitamin B6 vitamers (pyridoxine, pyridoxal, pyridoxamine) and their active coenzyme form, pyridoxal 5'-phosphate (PLP). This pathway plays a crucial role in a wide array of cellular functions, including amino acid metabolism, neurotransmitter synthesis, one-carbon metabolism, and immune function. Modulation of this pathway can impact neurological function, inflammatory responses, metabolic health, and cancer development, making it a potential therapeutic target for various diseases.

Other names

Pyridoxine pathwayPyridoxal pathwayPyridoxamine pathwayPLP metabolismVitamin B6 metabolism

Modulation of enzyme activity (e.g., inhibition or activation of PDXK, pyridox(am)ine phosphate oxidase, or aldehyde oxidase); altering vitamin B6 bioavailability or distribution; influencing expression of key enzymes in the pathway.