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Vitamin C Transporter (NA)
- Target
- NA
- Molecular classification
- Transporter, Solute Carrier, Sodium-dependent Vitamin C Transporter (SVCT), Facilitative Glucose Transporter (GLUT)
01
Overview
Vitamin C transporters are membrane proteins responsible for the cellular uptake and distribution of vitamin C (ascorbic acid) and its oxidized form, dehydroascorbic acid (DHA). The two main families are Sodium-dependent Vitamin C Transporters (SVCTs) and Facilitative Glucose Transporters (GLUTs). SVCT1 and SVCT2 mediate sodium-coupled co-transport of ascorbate. GLUT1, GLUT3, and GLUT4 transport DHA, which is then reduced to ascorbic acid intracellularly. These transporters are crucial for maintaining intracellular vitamin C levels for its various physiological roles.
- Other names
- Ascorbate TransporterDehydroascorbic Acid TransporterSVCT1SVCT2GLUT1 (as DHA transporter)GLUT3 (as DHA transporter)GLUT4 (as DHA transporter)
02
Mechanism of action
Sodium-coupled symport (SVCTs) or Facilitative diffusion (GLUTs)
03
Biological functions
Vitamin C transportAscorbate uptakeDehydroascorbic acid uptakeRegulation of intracellular ascorbate levelsAntioxidant transportCofactor transport
04
Disease associations
Scurvy (Vitamin C deficiency)Cancer (potential role in ascorbate delivery to cancer cells)Neurodegenerative diseases (related to oxidative stress and ascorbate levels)Cardiovascular disease (potential protective role of ascorbate)
05
Safety considerations
Potential for drug interactions affecting vitamin C transportVariability in transporter expression and functionRenal toxicity linked to excessive vitamin C dosages
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