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Target intelligence / Profile preview
Vitamin D3 Receptor
- Molecular classification
- Nuclear hormone receptor, Transcription factor
01
Overview
The Vitamin D3 receptor (VDR), also known as the calcitriol receptor or NR1I1, is a member of the nuclear hormone receptor superfamily. It functions as a ligand-dependent transcription factor that mediates the biological effects of vitamin D, particularly its active form, calcitriol (1,25-dihydroxyvitamin D3). VDR plays a central role in calcium and phosphate homeostasis and regulates gene expression involved in mineral metabolism, immune response, cell growth, differentiation, and apoptosis.
- Other names
- Calcitriol receptorNuclear vitamin D receptorNR1I1
02
Mechanism of action
Ligand-dependent transcription factor; forms heterodimer with RXR; binds to VDREs in target gene promoters/enhancers; modulates transcription by recruiting coactivators or corepressors.
03
Biological functions
Calcium/phosphate homeostasisImmunityCell growthCell differentiationApoptosisTranscriptional regulation
04
Disease associations
Chronic kidney diseaseHair/hair growth developmental defectHyperparathyroidismHypoparathyroidismMineral deficiencyPsoriasisVitamin deficiency syndromesInfectious diseases (e.g., AIDS)Enveloped virus infections
05
Safety considerations
Potential for hypercalcemia with excessive vitamin D supplementationVariations in *VDR* gene can influence disease susceptibility and progression.
06
Interacting drugs
Calcitriol
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