Vitamin-dependent enzymes

Vitamin-dependent enzymes are a heterogeneous class of enzymes that require vitamins as cofactors or coenzymes—a role critical for diverse cellular processes, especially metabolic pathways. Typical examples include enzymes utilizing vitamin B6 (pyridoxal phosphate), vitamin B2 (flavin adenine dinucleotide, FAD), vitamin B3 (NAD/NADP), and vitamin B12 (cobalamin) as cofactors[1][4][6]. These enzymes are integral to amino acid synthesis and degradation, neurotransmitter production, redox reactions in energy metabolism, and biosynthesis of heme and nucleic acids[1][3][4][9]. While individual vitamin-dependent enzymes can be direct therapeutic targets (e.g., monoamine oxidase, thiamine-dependent pyruvate dehydrogenase), "vitamin-dependent enzymes" as a collective does not constitute a single, actionable pharmacological target. In summary, "Vitamin-dependent enzymes" is a descriptive, functional category but is not specific enough for drug targeting or structured database inclusion as a canonical molecular target[1][6].

Other names

Vitamin-requiring enzymesVitamin coenzyme-dependent enzymesVitamin-dependent catalysis