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Target intelligence / Profile preview
Vitamin K-dependent Clotting Pathway (VKDCP)
- Target
- VKDCP
- Molecular classification
- Enzyme Cascade, Coagulation Factors, Regulatory Proteins
01
Overview
The vitamin K-dependent clotting pathway involves a group of coagulation factors (II, VII, IX, X) and regulatory proteins (Protein C, S, Z) that require vitamin K for gamma-carboxylation of glutamate residues. This modification is crucial for calcium binding and membrane interaction, essential steps in the coagulation cascade. Dysfunction in this pathway can lead to bleeding or thrombotic disorders. Warfarin inhibits this pathway via inhibition of VKORC1.
- Other names
- Vitamin K-dependent coagulation factorsVitamin K cycleVitamin K-dependent proteinsCoagulation Cascade (Vitamin K Dependent)
02
Mechanism of action
Inhibition of vitamin K epoxide reductase (VKORC1) leading to decreased synthesis of functional clotting factors.
03
Biological functions
Blood coagulationHemostasisRegulation of coagulation cascadeCalcium bindingMembrane association
04
Disease associations
Bleeding disordersThrombosisHemorrhagic diseaseCardiovascular disease
05
Safety considerations
Bleeding riskThrombosis risk (with certain mutations or imbalances)Drug interactions (especially with anticoagulants)
06
Interacting drugs
Warfarin
2 more in the full profile.
07
Biomarkers
Prothrombin time (PT)International Normalized Ratio (INR)Levels of Factors II, VII, IX, XProtein C and S activity
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