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Target intelligence / Profile preview
Vitamin K epoxide reductase (VKOR)
- Target
- VKOR
- Molecular classification
- Enzyme, Reductase, Integral membrane protein
01
Overview
Vitamin K epoxide reductase (VKOR) is an integral membrane enzyme crucial for the vitamin K cycle. It catalyzes the reduction of vitamin K 2,3-epoxide and vitamin K to vitamin K hydroquinone, which is a necessary cofactor for the gamma-glutamyl carboxylation of specific proteins, most notably those involved in blood coagulation. VKOR is highly sensitive to inhibition by warfarin—the most widely prescribed oral anticoagulant.
- Other names
- VKORC1Vitamin K epoxide reductase complex subunit 1
02
Mechanism of action
Inhibition of Vitamin K epoxide reductase
03
Biological functions
Vitamin K recyclingGamma-glutamyl carboxylationHemostasisCalcium homeostasisGrowth controlSignal transductionApoptosisAngiogenesis (possibly)
04
Disease associations
Blood coagulation disordersCardiovascular disease
05
Safety considerations
Bleeding risk with warfarin inhibition
06
Interacting drugs
Warfarin
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