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Target intelligence / Profile preview
Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1)
- Target
- VKORC1
- Molecular classification
- Enzyme, Integral membrane protein
01
Overview
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is an integral membrane protein and the catalytic subunit of the vitamin K epoxide reductase (VKOR) complex. It is essential for the vitamin K cycle, reducing vitamin K epoxide to its active hydroquinone form, which is required for activating blood-clotting factors. VKORC1 is the target of warfarin and other coumarin anticoagulants; genetic variations in VKORC1 significantly influence individual responses to these drugs.
- Other names
- Vitamin k epoxide reductase complexVitamin k epoxide reductase complex subunit 1
02
Mechanism of action
Inhibition of VKORC1 activity, leading to reduced active vitamin K and impaired activation of clotting factors.
03
Biological functions
Redox reactionVitamin K cycleBlood coagulation
04
Disease associations
Warfarin resistanceWarfarin sensitivityCardiovascular disease (related to coagulation)
05
Safety considerations
Risk of bleeding complications during anticoagulant therapyIndividual variability in response to warfarin due to VKORC1 polymorphisms
06
Interacting drugs
Warfarin
1 more in the full profile.
07
Biomarkers
VKORC1 polymorphisms (e.g., Asp36Tyr substitution) for warfarin sensitivity/resistanceVKORC1 genotype for personalized anticoagulant dosing
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