Target intelligence / Profile preview

Vitreomacular Adhesion (VMA)

Target: VMA
Molecular classification: Anatomical/Clinical Condition

Overview

Vitreomacular adhesion (VMA) is a condition where the vitreous gel (vitreous humor) of the eye adheres abnormally strongly to the macula, which is part of the retina responsible for central vision. Normally, as people age, the vitreous separates from the retina. However, if this separation is incomplete and an adhesion remains at or near the macula, it can create pulling forces on retinal tissue. The adhesion itself may be asymptomatic but can lead to pathological conditions if traction develops.

Mechanism of action

Ocriplasmin enzymatically induces separation between vitreous and retina.

Biological functions

Incomplete posterior vitreous detachment with persistent focal adhesionAdhesion of the vitreous gel to the macula

Disease associations

Vitreomacular traction syndrome (VMTS)Macular holeEpiretinal membrane (ERM)Diabetic macular edema (DME)Age-related macular degeneration (AMD)Retinal vein occlusionRetinal tears and detachment

Interacting drugs

Ocriplasmin

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