Target intelligence / Profile preview

Vitreous Cavity (Internal Tamponade)

Molecular classification
Physical Agent, Medical Device, Gas, Silicone Oil, Heavy Silicone Oil, Perfluorocarbon Liquid
01

Overview

Internal tamponade agents are substances used in vitreoretinal surgery to provide mechanical support and prevent fluid from accumulating under the retina, facilitating its reattachment. These agents include gases (air, SF₆, C₂F₆, C₃F₈), silicone oils, and heavy silicone oils/perfluorocarbon liquids. They function based on physical properties like surface tension and buoyancy, rather than through biological interactions. Their use is indicated in retinal detachment, macular hole repair, and proliferative vitreoretinopathy. Potential complications include cataract formation, glaucoma, and re-detachment.

Other names
Intravitreal TamponadeRetinal TamponadeVitreous ReplacementInternal Tamponade Agents
02

Mechanism of action

Mechanical barrier against subretinal fluid ingress, supporting retinal reattachment through surface tension and buoyancy.

03

Biological functions

Mechanical SupportFluid BarrierRetinal Reattachment
04

Disease associations

Retinal DetachmentMacular HoleProliferative Vitreoretinopathy
05

Safety considerations

Cataract formationElevated intraocular pressure/glaucomaEmulsification/migration (silicone oil)Re-detachmentInflammationToxicity (heavy silicone oils/perfluorocarbon liquids)

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