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Target intelligence / Profile preview
Vitronectin (VTN)
- Target
- VTN
- Molecular classification
- Glycoprotein, Extracellular matrix protein, Adhesion protein
01
Overview
Vitronectin (VTN), also known as serum spreading factor or S-protein, is a multifunctional glycoprotein found in plasma and the extracellular matrix. It plays crucial roles in cell adhesion, spreading, migration, tissue remodeling, hemostasis, immune defense, and ECM regulation. Vitronectin binds to integrins, particularly αvβ3 and αvβ5, via its RGD motif, mediating cell-substrate interactions. It's involved in various physiological and pathological processes, including cancer, neurodegenerative diseases, and infectious diseases.
- Other names
- VNSerum spreading factorS-proteinV75
02
Biological functions
Cell adhesionCell spreadingCell migrationTissue remodelingHemostasisImmune defenseECM regulationPluripotency maintenanceNeural differentiationNeurogenesisAxon guidanceNeurite extension
03
Disease associations
CancerNeurodegenerative diseases (e.g., Alzheimer's disease)Infectious diseases
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