VKORC1-PRSS53 readthrough protein (VKORC1-PRSS53)

The term refers to a readthrough (fusion) transcript arising from transcriptional readthrough between the **VKORC1** (Vitamin K epoxide reductase complex subunit 1) and **PRSS53** (Serine protease 53) genes. Readthrough transcripts are mRNA molecules generated when transcription continues from one gene directly into the next, sometimes creating a hybrid protein, but in most cases, these do not correspond to well-defined or functional protein products. Major functional, disease, or therapeutic targeting attributes are unknown for this specific readthrough product. The individual genes involved—VKORC1 and PRSS53—are well-characterized, but this fusion is not considered a validated therapeutic target and does not map to a typical, druggable protein entity[6].

Other names

VKORC1-PRSS53 fusionVKORC1-PRSS53 readthroughENSG00000255439