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Target intelligence / Profile preview
Voltage-Dependent Anion Channel (VDAC)
- Target
- VDAC
- Molecular classification
- Ion channel, β-barrel protein, Porin
01
Overview
The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is a β-barrel membrane protein predominantly located in the outer mitochondrial membrane (OMM). VDAC forms the primary pathway for the exchange of ions and metabolites between mitochondria and the cytosol, playing a central role in cellular energy metabolism and apoptosis regulation.
- Other names
- Mitochondrial porin
02
Mechanism of action
Modulation of VDAC activity to influence cell energetics and apoptosis
03
Biological functions
Regulation of metabolic fluxATP/ADP transportCalcium ion transportApoptosis regulation
04
Disease associations
Parkinson's diseaseFriedreich’s ataxiaLupusCancerNeurodegenerative diseaseAutoimmune disorders
05
Safety considerations
Altered metabolite exchangeDysregulated apoptosisOff-target effects on mitochondrial function
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