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Target intelligence / Profile preview
Voltage-dependent anion channel 1 (VDAC1)
- Target
- VDAC1
- Molecular classification
- Ion channel, Transporter
01
Overview
Voltage-dependent anion channel 1 (VDAC1) is a major mitochondrial outer membrane protein that facilitates the transport of ions and metabolites across the membrane. It plays a critical role in cellular energy metabolism, apoptosis, and calcium signaling. Dysregulation of VDAC1 is implicated in various diseases, including cancer, neurodegenerative disorders, and diabetes, making it a potential therapeutic target.
02
Mechanism of action
Channel modulation; Inhibition of protein-protein interactions
03
Biological functions
Energy metabolism regulationApoptosis modulationIon transportMetabolite transport
04
Disease associations
CancerNeurodegenerative diseaseType 2 DiabetesCardiac ischemia/reperfusion injury
05
Safety considerations
Off-target effects due to ubiquitous expressionPotential disruption of cellular metabolism and apoptosis
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