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Voltage dependent anion channel 1 pseudogene 8 (VDAC1P8)
- Target
- VDAC1P8
- Molecular classification
- Pseudogene, Noncoding RNA (in its transcribed form), Related to ion channel family (as a pseudogene derived from VDAC1)
01
Overview
Voltage dependent anion channel 1 pseudogene 8 (VDAC1P8) is one of multiple human pseudogenes derived from the gene encoding voltage-dependent anion channel 1 (VDAC1), a mitochondrial ion channel involved in cellular metabolism and apoptosis. Unlike its parental gene, VDAC1P8 typically does not encode a functional protein. Recent research demonstrates that VDAC1P8 is transcribed in specific tissues, particularly showing high expression in acute myeloid leukemia where its overexpression is correlated with reduced VDAC1 levels, suggesting a regulatory role through a noncoding RNA mechanism. VDAC1P8 is thus a member of the growing class of pseudogenes with putative roles in gene regulation, especially in cancer biology[4][5].
- Other names
- VDAC1P8Voltage-dependent anion selective channel 1 pseudogene 8VDAC1 pseudogene 8
02
Mechanism of action
None known for drugs; VDAC1P8 may act by modulating RNA networks as a ceRNA, but there is no direct mechanism of action relevant to therapies[4][5].
03
Biological functions
Competing endogenous RNA (ceRNA) functionRegulation of parental gene (VDAC1) expressionAssociation with gene regulatory networks in acute myeloid leukemia (AML)[4][5]
04
Disease associations
Acute myeloid leukemia (AML): VDAC1P8 is specifically overexpressed in AML and exhibits a regulatory relationship with parental VDAC1 gene expression[4][5].
05
Biomarkers
Overexpression of VDAC1P8 in AML cellular models may serve as a biomarker for disease presence or for the downregulation of the parental VDAC1 gene in AML[4][5].
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