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Voltage-dependent anion channel 2

Molecular classification: Voltage-dependent anion channel family, Ion channel

Overview

Voltage-dependent anion channel 2 (VDAC2) is a pore-forming protein located in the outer mitochondrial membrane. It facilitates metabolite exchange between mitochondria and the cytosol, playing key roles in cellular energy metabolism, apoptosis regulation, and calcium signaling. VDAC2 mediates local calcium transfer from sarcoplasmic reticulum to mitochondria and is implicated in cardiopulmonary diseases, spermatogenesis, and immune response.

Biological functions

Metabolite transportRegulation of apoptosisCalcium signalingEnergy metabolism regulationImmune response modulationCardiac contraction regulationRegulation of metabolic and energetic flux

Disease associations

Cardiopulmonary diseases

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