Voltage-dependent anion channel 3 pseudogene (None)

The voltage-dependent anion channel 3 pseudogene (LOC100420647, ENSG00000226671) is a non-protein-coding DNA sequence resembling the functional VDAC3 gene, which encodes a mitochondrial ion channel involved in cellular metabolism and mitochondrial signaling[5][7]. As a pseudogene, it does not encode a functional protein; however, some pseudogenes may play roles in gene regulation through noncoding RNA mechanisms like RNA interference or miRNA decoy, though such activity is not confirmed for this specific pseudogene[6]. It is not considered a therapeutic target and should not be confused with the functional Voltage-dependent anion channel protein 3 (VDAC3), which operates as a mitochondrial channel and has established roles in cell viability and disease states[5][7]. Key clarification: - If the intent was to identify the functional ion channel “Voltage-dependent anion-selective channel protein 3” (VDAC3), it is encoded by a different, non-pseudogene locus. - If searching for a therapeutic target or biomarker, refer to the functional **VDAC3 protein**, not its pseudogene[5][7]. Summary of issues: - The pseudogene is neither a druggable target nor a functional protein. - No clinically relevant molecular, functional, or disease information is associated with this pseudogene. - Abbreviations like VDAC3 properly refer to the functional gene/protein, not the pseudogene.

Other names

LOC100420647Voltage-dependent anion channel 3 pseudogeneENSG00000226671

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