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Target intelligence / Profile preview
Voltage-dependent anion-selective channel protein 2 (VDAC2)
- Target
- VDAC2
- Molecular classification
- Ion channel, Porin, Voltage-gated channel
01
Overview
VDAC2 is a voltage-gated ion channel located in the outer mitochondrial membrane. It regulates metabolite exchange between mitochondria and cytosol, participates in apoptosis regulation through interactions with BCL-2 family proteins like BAK, and is involved in calcium homeostasis. It also acts as a binding site for kinases and plays roles in cardiac contraction, pulmonary circulation, spermatogenesis, and immune response. Dysregulation can contribute to cardiopulmonary diseases or altered immune responses.
- Other names
- Outer mitochondrial membrane protein porin 2hVDAC2VDAC-2
02
Biological functions
Regulation of cell metabolismMetabolite exchangeApoptosis regulationCalcium homeostasisCardiac muscle contractionPulmonary circulationSpermatogenesisImmune responsePhospholipid scrambling
03
Disease associations
Cardiopulmonary diseasesAltered immune responses
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