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Target intelligence / Profile preview
Voltage-dependent anion-selective channel protein 3 (VDAC3)
- Target
- VDAC3
- Molecular classification
- Ion channel, Porin
01
Overview
Voltage-dependent anion-selective channel protein 3 (VDAC3) is a pore-forming protein located in the outer mitochondrial membrane. It functions as an ion channel with mild preference for anions over cations and plays roles in sperm flagella/centriole assembly, mitochondrial quality control (via mitophagy), and may act as a sensor for oxidative stress. Mutations or dysregulation of VDAC3 have been associated with male infertility and neurodegenerative diseases such as Parkinson’s disease.
- Other names
- HD-VDAC-3voltage dependent anion channel 3
02
Biological functions
Ion/metabolite transportSperm flagella assemblyCentriole assemblyMitochondrial quality controlOxidative stress sensing
03
Disease associations
Male infertilityNeurodegenerative diseaseParkinson's disease
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