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Target intelligence / Profile preview
Voltage-gated calcium channel (VGCC)
- Target
- VGCC
- Molecular classification
- Ion channel, Voltage-gated ion channel
01
Overview
Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a family of transmembrane ion channels found in the membranes of excitable cells such as neurons, muscle cells, and some endocrine cells. They play a critical role in converting changes in membrane potential into intracellular calcium signals that trigger various physiological processes.
- Other names
- Voltage-dependent calcium channelVDCC
02
Mechanism of action
Inhibition of calcium influx through the channel pore
03
Biological functions
Muscle contractionNeurotransmitter releaseHormone secretionGene expression regulationRegulation of neuronal excitabilityPacemaking activity
04
Disease associations
Cardiac arrhythmiaEpilepsyChronic pain syndromesNeurodegenerative diseaseHypertension
05
Safety considerations
Cardiac side effectsNeurological side effects
06
Interacting drugs
Dihydropyridines
1 more in the full profile.
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