Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Voltage-dependent Calcium Channel α2δ Subunit (α2δ)
- Target
- α2δ
- Molecular classification
- Ion channel subunit, Voltage-gated calcium channel subunit, Auxiliary subunit
01
Overview
The voltage-dependent calcium channel α2δ subunit is an auxiliary protein component of high-voltage-activated calcium channels, primarily associated with CaV1 and CaV2 channel types. It plays a crucial role in modulating the trafficking, expression, and biophysical properties of these channels. It is the binding site for gabapentinoid drugs used for neuropathic pain.
- Other names
- CACNA2D subunitCalcium channel auxiliary subunit α2δ
02
Mechanism of action
Binding to the α2δ subunit of voltage-dependent calcium channels, leading to reduced calcium influx and decreased neurotransmitter release.
03
Biological functions
Calcium channel modulationChannel traffickingRegulation of channel expressionSynaptogenesis
04
Disease associations
Neuropathic painEpilepsyAutism Spectrum Disorder
05
Safety considerations
Potential for central nervous system depressionRisk of abuse and dependence
06
Interacting drugs
Gabapentin
2 more in the full profile.
Beyond the preview
Go deeper on Voltage-dependent Calcium Channel α2δ Subunit (α2δ).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Voltage-dependent Calcium Channel α2δ Subunit (α2δ).