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Target intelligence / Profile preview
Voltage-dependent calcium channel beta-2 subunit (CACNB2)
- Target
- CACNB2
- Molecular classification
- Ion channel, Voltage-gated calcium channel auxiliary subunit
01
Overview
The voltage-dependent calcium channel beta-2 subunit (CACNB2) is a cytosolic, auxiliary protein of the voltage-gated calcium channel complex. It controls channel trafficking to the plasma membrane, regulates channel opening and closing (gating) kinetics, and is essential for proper electrical signaling in excitable tissues, especially the heart and nervous system. Mutations in CACNB2 are linked to cardiac arrhythmias (such as Brugada and short QT syndromes) and possibly neuropsychiatric disease. While not a direct drug target, its role is crucial for the function of therapeutic agents that target voltage-gated calcium channels[1][2][3][4][5][6].
- Other names
- Cavβ2CACNB2calcium channel, voltage-dependent, beta 2 subunitbeta-2
02
Mechanism of action
Modulation of channel surface expression and channel gating to influence calcium influx; drugs generally block the α1 subunit's pore, with auxiliary beta-2 influencing drug sensitivity and channel properties[5].
03
Biological functions
Modulation of voltage-gated calcium channel trafficking and surface expressionRegulation of channel gating and kineticsParticipation in signal transduction
04
Disease associations
Cardiovascular diseaseSudden cardiac death syndromes (e.g., short QT syndrome, Brugada syndrome)Neuropsychiatric disorders
05
Safety considerations
Altering activity or expression can cause severe cardiac side effects (arrhythmia, sudden death)embryonic lethality in knockout models[1]
06
Interacting drugs
verapamil
2 more in the full profile.
07
Biomarkers
Mutations in CACNB2 may serve as biomarkers for cardiac arrhythmia syndromes[1]
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