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Target intelligence / Profile preview
Voltage-dependent calcium channel gamma-1 subunit (CACNG1)
- Target
- CACNG1
- Molecular classification
- Ion channel subunit, PMP22/EMP/MP20 superfamily, Voltage-gated calcium channel subunit, Auxiliary subunit
01
Overview
The voltage-dependent calcium channel gamma-1 subunit is a regulatory protein that forms part of the L-type voltage-gated calcium channels, specifically in skeletal muscle. It is encoded by the CACNG1 gene. This subunit modulates the function of the channel complex, particularly influencing channel inactivation kinetics and contributing to excitation-contraction coupling in muscle tissue. Its expression appears to be exclusive or highly enriched in skeletal muscle cells. While no specific diseases are directly attributed solely to mutations or dysfunctions in CACNG1 at present, its critical role suggests that alterations could potentially impact muscular function or contribute to disorders involving excitation-contraction coupling.
- Other names
- CACNLGcalcium voltage-gated channel auxiliary subunit gamma 1
02
Mechanism of action
Modulates the activity of L-type voltage-gated calcium channels, affecting calcium influx into cells.
03
Biological functions
Regulation of L-type Ca²⁺ currentModulation of channel kineticsExcitation-contraction couplingCalcium ion transport
04
Safety considerations
Potential for affecting muscle contraction and function if dysregulated.
05
Interacting drugs
Dihydropyridines (e.g., Nifedipine, Amlodipine)
2 more in the full profile.
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