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Target intelligence / Profile preview
Voltage-dependent calcium channel gamma-like subunit (TMEM37)
- Target
- TMEM37
- Molecular classification
- Ion channel subunit, Transmembrane protein
01
Overview
Voltage-dependent calcium channel gamma-like subunit (TMEM37) is a transmembrane protein primarily known for its role as an auxiliary subunit of voltage-gated calcium channels, where it is thought to stabilize the channel in the inactivated (closed) state and modulate calcium current when co-expressed with the T-type calcium channel subunit CACNA1G[1][2][4][8][10]. TMEM37 is located in the membrane and is expressed in multiple human tissues[5]. There is no current evidence that it is a direct therapeutic target or that specific drugs interact directly with this subunit. TMEM37 has been implicated in the regulation of calcium ion flow but is not classified as a standalone channel, receptor, or principal drug target[9][10].
- Other names
- Transmembrane protein 37TMEM37PRPR1Neuronal voltage-gated calcium channel gamma-like subunitVoltage-dependent calcium channel gamma subunit-like proteinCCGL
02
Biological functions
Calcium channel stabilizationModulation of calcium currentRegulation of ion transmembrane transport
03
Disease associations
Other (associated with Necatoriasis and Schizophrenia 14, but no direct evidence as a disease driver)[4]
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