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Target intelligence / Profile preview
Voltage-dependent calcium channel subunit alpha-1
- Molecular classification
- Ion channel, Voltage-gated calcium channel subunit, Transmembrane protein
01
Overview
The voltage-dependent calcium channel subunit alpha-1 is the principal pore-forming component of voltage-gated calcium channels (VGCCs). It mediates calcium influx into cells upon membrane depolarization, triggering downstream processes such as neurotransmitter release, muscle contraction, and hormone secretion. There are multiple isoforms (L-, P/Q-, N-, R-, T-types) with distinct tissue distribution and physiological roles. Mutations or dysregulation can cause various diseases, including cardiac arrhythmias, epilepsy, and ataxia.
- Other names
- VGCC alpha-1 subunitCaVα1 subunit
02
Mechanism of action
Channel blockade
03
Biological functions
Calcium ion transmembrane transportRegulation of membrane potentialNeurotransmitter releaseMuscle contractionHormone secretionGene transcription regulationCell motilityCell divisionCell growthSynaptic transmissionPacemaking activity
04
Disease associations
Cardiac arrhythmiasEpilepsyAtaxiaAutism spectrum disorder
05
Safety considerations
Cardiac side effectsNeurological side effects
06
Interacting drugs
Dihydropyridines
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