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Target intelligence / Profile preview
Voltage-dependent calcium channel subunit alpha2-delta1 (CACNA2D1)
- Target
- CACNA2D1
- Molecular classification
- Ion channel subunit, Voltage-gated calcium channel subunit, Calcium channel auxiliary subunit
01
Overview
The alpha2-delta1 subunit is a component of voltage-dependent calcium channels, essential for calcium influx. It regulates channel density, modifies kinetics, and plays a role in excitation-contraction coupling. It's targeted by gabapentinoids for treating epilepsy, neuropathic pain, and anxiety disorders. Dysregulation is associated with neuropathic pain and other conditions.
- Other names
- CACNL2ACCHL2AMHS3Voltage-gated calcium channel subunit alpha-2/delta-1
02
Mechanism of action
Gabapentinoids bind to alpha2-delta isoforms 1 and 2 to modulate synaptic transmission.
03
Biological functions
Regulation of calcium channel densityModulation of calcium channel kineticsExcitation-contraction couplingSynaptogenesisExcitatory neurotransmission modulation
04
Disease associations
Neuropathic painEpilepsyCardiac arrhythmiaPsychiatric disordersCancer
05
Safety considerations
Side effects associated with gabapentinoids
06
Interacting drugs
Gabapentin
1 more in the full profile.
07
Biomarkers
Potential cancer biomarker
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