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Voltage-dependent calcium channel subunit alpha2-delta2 (α2δ-2)
- Target
- α2δ-2
- Molecular classification
- Voltage-gated Calcium Channel Auxiliary Subunit
01
Overview
The voltage-dependent calcium channel subunit alpha2-delta2 (α2δ-2) is an auxiliary protein component of high-voltage-activated (HVA) calcium channels, encoded by the CACNA2D2 gene. It regulates calcium current density, modulates activation and inactivation kinetics, and influences trafficking and surface expression of associated calcium channels like P/Q-, N-, and L-type. It plays a role in synapse organization and, in neurons, limits axon growth/regeneration. α2δ-2 is a target for gabapentinoid drugs used to treat epilepsy and neuropathic pain.
02
Mechanism of action
Gabapentinoids bind to the α2δ subunits, especially isoforms 1 and 2, of voltage-dependent calcium channels, modulating calcium influx and reducing the release of excitatory neurotransmitters.
03
Biological functions
Regulation of calcium current densityModulation of calcium channel kineticsRegulation of trafficking and surface expression of calcium channelsSynapse organizationRegulation of axon growth/regeneration
04
Disease associations
EpilepsyNeuropathic painDiabetic neuropathyNeuralgiaInflammation-related painChemotherapy-induced peripheral neuropathyCentral nervous system disorders
05
Interacting drugs
Gabapentin
1 more in the full profile.
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