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Voltage-dependent calcium channel subunit alpha2delta 1
- Molecular classification
- Voltage-gated ion channel, Alpha–subunits of voltage-dependent Ca²⁺ channels
01
Overview
CACNA2D1 encodes the voltage-dependent calcium channel subunit alpha-2/delta-1, a key auxiliary component of the voltage-gated calcium channel complex. It regulates calcium current density and modulates activation/inactivation kinetics of the main pore-forming subunit. Dysregulation is linked to various diseases, and it is a molecular target for gabapentinoid drugs used to treat epilepsy and neuropathic pain.
- Other names
- Voltage-gated calcium channel subunit alpha-2/delta-1MHS3CCHL2ACACNL2ACACNA2D1
02
Mechanism of action
Gabapentinoids bind to the α₂δ₁ and α₂δ₂ isoforms of the voltage-dependent calcium channel, modulating calcium influx and reducing neurotransmitter release. Ziconotide blocks N-type calcium channels.
03
Biological functions
Regulation of calcium current density and kineticsExcitation-contraction couplingSynaptic transmissionNeurotransmitter releaseSynaptogenesisSynaptic plasticity
04
Disease associations
Early-onset developmental epileptic encephalopathyColon cancer progressionDiabetes susceptibilityNeuropathic painChronic obstructive pulmonary disease (COPD)Hypertension
05
Interacting drugs
Gabapentin
2 more in the full profile.
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