Voltage-dependent calcium channel subunit gamma-1 (CACNG1)

Voltage-dependent calcium channel subunit gamma-1 (CACNG1) is a transmembrane protein that serves as an auxiliary subunit of the skeletal muscle L-type voltage-gated calcium channel (CaV1.1) complex (Wikipedia, UniProt). It plays a critical role in excitation-contraction coupling by modulating the inactivation kinetics and voltage-dependence of the channel, thereby regulating calcium influx into myocytes (PubMed: 8387489, genenames.org). Beyond its role in muscle physiology, CACNG1 has been identified as a lineage repressor of white adipose tissue beiging, suggesting a potential role in metabolic regulation and obesity (patsnap.com). In the pharmaceutical industry, CACNG1 is being explored as a target for muscle-specific drug delivery, such as antibody-siRNA conjugates (e.g., by Regeneron) designed to treat musculoskeletal disorders like myotonic dystrophy (patsnap.com, google.com/patents). While traditional L-type calcium channel blockers like diltiazem interact with the overall channel complex, specific modulation of the gamma-1 subunit offers a pathway to influence muscle-specific calcium signaling (guidetopharmacology.org).

Other names

CACNLGCalcium voltage-gated channel auxiliary subunit gamma 1Dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit gammaL-type calcium channel gamma polypeptide

CACNG1 modulates the gating properties of the CaV1.1 channel complex, specifically accelerating inactivation and shifting the voltage-dependence of activation (UniProt). As a therapeutic target, it is utilized for the muscle-specific delivery of siRNA or other cargoes via antibody conjugation, and its inhibition is explored for treating metabolic and cardiovascular conditions (patsnap.com, google.com/patents).