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Target intelligence / Profile preview
Voltage-dependent L-type Calcium Channel Subunit Alpha (L-type Calcium Channel)
- Target
- L-type Calcium Channel
- Molecular classification
- Ion channel, Voltage-gated ion channel, Calcium channel
01
Overview
The voltage-dependent L-type calcium channel is a high-voltage-activated ion channel that mediates the influx of Ca\(^{2+}\) ions into excitable cells, such as cardiac, skeletal, and smooth muscle cells. This influx is crucial for processes including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. The L-type channel is especially important in excitation-contraction coupling in muscles and plays a key role in cardiac action potentials.
- Other names
- L-type calcium channelDHPR (Dihydropyridine Receptor)
02
Mechanism of action
Calcium channel blockade
03
Biological functions
Muscle contraction regulationCardiac pacemakingAction potential propagationAldosterone secretionGene expression regulation
04
Disease associations
Cardiovascular diseaseHypertensionArrhythmiaHeart failure
05
Safety considerations
HypotensionBradycardiaAV block
06
Interacting drugs
Dihydropyridines (DHPs)
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